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Psychedelic Therapy 101: Navigating Your Ketamine Experience

As you approach your first Mindbloom visit, you may be asking yourself:

  • “What will happen during my first Mindbloom session?”
  • "After I take the medicine, what do I do?"
  • “What should I think about?”
  • “Will I be talking with my clinician during my treatment?”

In this article, we’ll cover exactly what to expect heading into your first treatment and how the “TLO” mantra will help you navigate the experience.

What you should know going into your first treatment

In a previous article, we talked about setting intentions before treatment. Even with your thoughtful focus on intentions, psychedelics can still unlock unexpected subconscious material. That’s why we ask our clients to set intentions, not an agenda, and cultivate a positive and open mindset heading into treatment. Here are some more important points to keep in mind for your first experience:

You’re entering uncharted territory

You’ll work with your clinician to find an appropriate therapeutic dose during your first couple of sessions. Even with a conservative initial dose, the medicine causes changes in your physical and mental perception and allows you to explore sometimes hidden parts of your consciousness. Read our article, “How will I feel during treatment,” if you want to learn more.

You’re here to learn

You’re doing this to learn and gain insights into your thoughts, emotions, and behaviors. Approach the experience with an attitude of curiosity and exploration. We advise clients to use their session to collect experiences that you can reflect upon and start to decode while journaling in our integration space after your session, and in the days and weeks that follow.

If you encounter anything during your exploration that causes fear, sadness, anger or any other uncomfortable emotion, remember that anything that is coming up in your mind is there not to harm you, but to enlighten you. Treat these ‘guardians of the threshold’ with openness and curiosity – they’re not monsters, they’re teachers. Have compassion for the fact that they have carried the burden of these difficult emotions for so long, and thank them for bringing them into the light of your awareness for healing and integration.

You’re safe

You’re in a medical practice with professional clinicians, medication from a licensed pharmacy, and a carefully curated environment to support your wellbeing. During treatment, you’ll be in a comfortable zero gravity chair with an eye mask and hand-selected meditations and music for your journey. You can also press your call button any time for immediate support.

How to navigate your experience

Even if you’re familiar with psychedelics, you may feel uneasy or excited for your first Mindbloom visit. Don’t worry - your clinician will help you prepare both your intentions and expectations during your initial video consultation and at the start of your Mindbloom visit.

Before taking the medicine, your clinician will help you prime your mind for the experience. Immediately after, you’ll use journaling to help develop and solidify your insights and new perspectives and then debrief your session with your clinician.

You may wonder if you’ll be doing 1:1 therapy during your treatment. In a way, you will! Not with your clinician, but with your own psyche. Your Mindbloom psychedelic therapy sessions are designed to facilitate inner exploration, where you’ll dive into your own mind. The goal isn’t to focus on anything specific, but to embrace what comes up.

Throughout your journey, we encourage you to practice a classic psychedelic mantra that will help guide you: trust, let go, be open.

TLO - Trust, Let Go, Be Open

“Trust, Let go, be Open” or TLO, is a mantra that is widely used in psychedelic therapy. From pioneers such as Stan Grof and Betty Eisner to today’s sessions at Johns Hopkins and NYU, the TLO mantra helps voyagers get the most out of their experiences.


Trust that you've been prepared by expert Clinicians to dive deep into the issues that are holding you back from living your best life, without compromising your physical or psychological well-being. Trust that the medicine will serve its purpose.

Trust your own Inner Healing Intelligence, and trust that you have the skills and natural abilities to achieve profound insights and healing from this experience.

Let go

Letting go is crucial to psychedelic therapy. Let go of expectations about what should or shouldn’t happen to your mind or body. Let go of concerns and judgments, as well as the inevitable urge to control the experience. Whatever happens, happens – let it unfold. Your mind will give you what you need.

If the experience is challenging, confront whatever frightens you. Betty Eisner, a psychedelic therapy pioneer, explains:

Then there was the most important information for a therapeutic session, the suggestion that the subject should allow IT (whatever) to happen… “Move toward the problem!” In other words, one should go into the fire, toward the dragon, into the vortex, toward the void, toward that which is frightening. In a psychedelic session (as in life?), it is confronting the seemingly life-threatening situation that allows the problem to be solved and/or transcended… Life – or the deep unconscious – knows better than we do.

Be open

Be open and curious about whatever comes along in your journey. Your experience may be centered on your intentions – or it may not, and that’s okay. You may experience epiphanies or breakthroughs during your first experience, but don't be disappointed if they don't come right away. Benefits will compound over each session.

Be open to the events that are unfolding, whether profound or confusing, pleasant or challenging--there will be plenty of time to process and make sense of things later, if they don’t make sense right away. Stay open to the fundamental truth that everything happening is completely and utterly OK.

This article was reviewed by Casey Paleos MD, Medical Director of Mindbloom, Inc.



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Psychedelic Therapy 101: Navigating Your Ketamine Experience